Analyzing The Mutations Of Notch1 And Sf3b1 Genes In Cases With CLL Detected Isolated 13q Deletion

Chronic lymphocytic leukemia (CLL) is known as type of originating from clonal mature B lymphocytes and has genetic heterogeneity. Many studies have been done to clarify the genome CLL. In these studies, del(13q) reported most common chromosomal aberration. Although this anomaly associated with good prognosis when isolated, patients clinical addition, in many gene mutations including TP53, NOTCH1 SF3B1 mutations, poor identified. The prognostic significance genes begun be demonstrated. According data, we aimed determine mutation rate investigate effects (disease stages, TTFT OS) 43 cases isolated by using FISH method. We investigated CLL Sanger sequencing While frameshift 7541_7542delCT was detected 1 out 42 heterogeneity, couldn’t detected. As a result our study, it observed that weren’t which compatible literature data. Our study first evaluates parameters Turkish population. result; It concluded there may different reasons responsible for heterogeneity further are needed reveal